<b>Salvurmin A and Salvurmin B, Two Ursane Triterpenoids of Salvia urmiensis Induce Apoptosis and Cell Cycle Arrest in Human Lung Carcinoma Cells</b>

Background: Ursane triterpenoids could be considered as novel multi-target therapeutic anti-cancer agents. Salvurmin A and B are cytotoxic ursane isolated from the aerial parts of Salvia urmiensis, an endemic plant species Iran. Methods: In this study, we assessed cytotoxicity these compounds against two human cancer cell lines one normal line investigated its mechanism via apoptosis cycle arrest. Results: showed most effect on A549 cells compared to other studied cells. IC50 values for were 35.6 ± 1.5 19.2 0.8 µM, respectively. Based annexin V staining, both significantly induced in Moreover, increased accumulation G2/M decreased number G0/G1 phases a dose-dependent manner. Conclusion: results can potential candidate further studies lung carcinoma.